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"Epigenetic plasticity and antiangrogen resistance in prostate cancer"

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Synopsis: David W. Goodrich, Ph.D. / Professor of Oncology / Associate Dean for Postdoctoral Education / Roswell Park Institute / NY
Start Time: Monday, February 26, 2018 12:00 PM
End Time: Monday, February 26, 2018 1:00 PM
Location: Life Sciences Building
Address: 145 Bevier Road
Campus: Busch
Room: Auditorium
City, State, Country: Piscataway, NJ US
Fee: N/A
Speaker: David W. Goodrich, Ph.D.
Sponsor: Department of Genetics
Category: Talk, Lecture, Seminar
Web Site: http://genetics.rutgers.edu/images/documents/Seminar_announcments/Goodrich_Flyer_2-26-18.pdf
Contact Name: Department of Genetics
Contact Email: carmona@dls.rutgers.edu
Contact Phone: (848) 445-1638
Additional Information: Evidence will be presented indicating RB1 loss drives transformation of prostate adenocarcinoma to neuroendocrine prostate cancer. This process is mediated by epigenetic reprogramming factors because inhibiting their activity reverses neuroendocrine transformation. I will discuss therapeutic implications and the wider relevance of this mechanism for therapeutic resistance to molecularly targeted therapies.
Target Audience: Current Students,  Researchers,  Visitors,  Commuters,  Donors & Supporters,  Undergraduate Students,  Graduate Students,  Prospective Students,  Faculty,  Staff,  Alumni,  General Public,  Parents & Families