Synopsis: Please join us for a seminar by Dr. Kou-San Ju, Assistant Professor, Department of Microbiology and the Division of Medicinal Chemistry and Pharmacognosy, Ohio State University
Start Time: Wednesday, November 13, 2019 1:00 PM
End Time: Wednesday, November 13, 2019 2:00 PM
Location: Marine Sciences Building
Address: 71 Dudley Road
Campus: George H. Cook
Room: Almapi
City, State, Country: New Brunswick, NJ US
Fee: N/A
Speaker: Dr. Kou-San Ju
Sponsor: Department Biochemistry and Microbiology and Dr. Gerben Zylstra
Category: Talk, Lecture, Seminar
Web Site: http://PostIt.rutgers.edu/uploads/KSJ%5F11%5F13%5F19%5FFerm%5FSem.pdf
Contact Name: Lindsay Robinson
Contact Email: lindsay.robinson@rutgers.edu
Contact Phone: (848) 932-5642
Additional Information: Summary: Dr. Ju's interdisciplinary research program is inspired by the metabolic diversity of microorganisms and the vast array of compounds they produce. Working at the interface of chemistry and biology, he combines approaches in chemistry, biochemistry, bioinformatics, genetics, and systems biology to discover new natural products, identify bioactivity and mode of action, and to decipher the metabolic basis of their biosynthesis. He has developed a genomics-driven platform for the discovery of natural products from actinobacteria, an important source of antibiotics, pharmaceuticals, and agrochemicals. In contrast to traditional bioactivity guided screening, he uses low-cost, high-throughput, sequencing technologies to first classify the biosynthetic potential of strains. Combining the systematic analysis of encoded natural product gene clusters with chemospecific detection of molecules and metabolomics, an emergent path to new compounds is paved that simultaneously bypasses the “re-discovery problem” of classical discovery. Most recently, he used this strategy to mine the genomes of 10,000 actinomycetes for phosphonic and phosphinic acids, discovering a multitude of new compounds and unexplored pathways for this understudied, but commercially proven, class of natural products.