BEGIN:VCALENDAR PRODID:-//Rutgers University//Calendar of Events//EN VERSION:2.0 CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:88705 ORGANIZER;CN=Wendie Cohick, DTSTART:20171117T091500 DTEND:20171117T101500 DTSTAMP:20170911T110836 SUMMARY:“IGF-1R is a suppressor of metastasis in Wnt1 driven mammary tumorigenesis” DESCRIPTION:Signaling through the IGF-1R is complex in breast cancers. We have generated a mouse line containing both MMTV-Wnt1 and MMTV-dnIGF-1R transgenes that leads to increased metastasis through increased cellular stress, an altered EMT phenotype, and an influx of tumor evasive immune cells. LOCATION:Foran Hall 138A 59 Dudley Road New Brunswick CLASS:PUBLIC END:VEVENT END:VCALENDAR